The Chelsea drugstore was opened in 1968 and had a very distinct front of glass and aluminium making it stand out in a street where most buildings would be of an older architecture.

The drugstore was modelled on Le Drugstore on  Boulevard St Germain in Paris, it contained bars, a pharmacy, cafes and a record store in the basement, it was open 16 hours a day, seven days a week. The drugstore's exterior, and one might presume it's clientele, so shocked the residents of Royal Avenue that they demanded to be cut off from The Kings road, which happened in 1971.

In the lyrics for 1969 track You Can't Always <a href="http://www.xlsmedicalyagtutucu.com/xls-medical-istah-azaltici.html" target="_self" title="xls medical iştah azaltıcı" style="text-decoration: none"><font color="#5C5C5C">istah azaltici</font></a> Get What You Want Mick Jagger wrote 'I went down to the Chelsea Drugstore to get your prescription filled'. It is debated what the track is actually about, though the reference to the Chelsea drugstore is clear enough as Mick Jagger lived in Chelsea.

The Drugstore also features in Stanley Kubrick's 1972 film A Clockwork Orange, main character Alex browsing the record shop, located in the basement of the drugstore.

In the present day, 2008, a McDonalds restaurant occupies the Chelsea drugstore.